آخرین محصولات
Organoselenium Compounds in Biology and Medicine: Synthesis, …
Selenium in biology: 18 selenium was long considered a poison until 1957 when Schwarz and Foltz identified it as an essential micronutrient. 19 Fifteen years later selenocysteine, the 21st amino acid, was discovered at the active site of glutathione peroxidase (GPx), establishing the role of selenium in mammals. 20 Since then, …
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Selenium, Selenoproteins, and Immunity
Adequate levels of bioavailable selenium are functionally important for several aspects of human biology including the central nervous system, the male reproductive biology, the endocrine system, muscle function, the cardiovascular system, and immunity [3,4]. Many pathological conditions involving the immune system can be affected by the ...
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The role of selenium in human conception and pregnancy
Selenium was discovered in the year 1817 by the Swedish chemist Jöns Jacob Berzelius. Initially, it had been perceived as a toxic element, but after 140 years, a study by Schwarz and Folt [1] demonstrated that Se is essential for human biology. Today, it is acknowledged as a trace element fundamental to human health.
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Intracellular Glutathione Peroxidases — Structure, Regulation, …
Glutathione peroxidase (glutathione:H 2 0 2 oxidoreductase E.C. 1.11.1.9) was discovered by Mills (1) in 1957 in his search for the factors that function in the protection of erythrocytes against oxidative hemolysis. Similarly, John Rotruck, working in Professor Hoekstra's laboratory, focused on GPX in his search for an enzymatic function that made selenium …
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Effects of nationwide addition of selenium to
Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population ... R.F. Burk (Ed.), Selenium in biology and human health, Springer-Verlag, New York (1994), pp. 198-218. Google Scholar [31] P. Knekt, A. Aromaa, J. Maatela, G. Alfthan, M ...
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The role of selenium in human conception and pregnancy
Biochemical properties of selenium. Selenium was discovered in the year 1817 by the Swedish chemist Jöns Jacob Berzelius. Initially, it had been perceived as a toxic element, but after 140 years, a study by Schwarz and Folt [1] demonstrated that Se is essential for human biology. Today, it is acknowledged as a trace element fundamental …
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12th International Symposium on Selenium in Biology and …
9:00-9:20 Sarah White-Springer "Beyond antioxidants: Selenium in Mitochondrial Biology" 9:20-9:40 McKayla Nicol "Macrophage Selenoproteins Inhibit Autophagy and Restrict Intracellular Replication ... selenium and zinc status at hospital admission" 11:40-Noon – Sharon Rozovsky "Human Selenoprotein S interactions with the SARS-CoV-2 ...
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Biological role of selenium in the organism of animals and humans
Selenoprotein P is involved in the transport of selenium to various tissues, acts as an agent that helps neutralize toxic effects and remove heavy metals (Pt, Hg), protecting Leydig cells from ...
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Selenium in Biology: Facts and Medical Perspectives
Selenium in Biology: Facts and Medical Perspectives. Abstract Several decades after the discovery of selenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21st proteinogenic amino acid, selenocysteine, have been identified, partially …
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The role of selenium metabolism and selenoproteins in cartilage
Abstract As an essential nutrient and trace element, selenium is required for living organisms and its beneficial roles in human health have been well recognized. The …
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Selenium-Catalyzed Reduction of Hydroperoxides in Chemistry and Biology
In biology, selenium is in the core of enzymes deputed to consuming excess of hydroperoxides, which are harmful for the cell, or to exploiting the chemical reaction of hydroperoxide reduction for signalling purpose. The same elementary reaction, which can be modelled as a nucleophilic attack of the selenolate anion to the peroxide O …
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Selenium in Biology: Facts and Medical Perspectives
Selenium is an indispensable trace element for all living organisms. It is an essential structural component of several selenium-dependent enzymes, which support the human body's defense mechanism.
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Selenium : Its Molecular Biology and Role in Human Health
Selenium: Its Molecular Biology and Role in Human Health Dolph L. Hatfield Limited preview - 2012 Dolph L. Hatfield, Marla J. Berry, Vadim N. Gladyshev Limited preview - 2007
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Selenium, Selenoproteins, and Immunity
Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The …
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Selenium
Main article: Selenium in biology. A number of correlative epidemiological studies have implicated selenium deficiency (measured by blood levels) in a number of serious or chronic diseases, such as cancer, [121] [122] diabetes, [121] HIV/AIDS, [123] and tuberculosis. In addition, selenium supplementation has been found to be a …
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Selenium in the Environment, Metabolism and Involvement in …
Selenium () is a metalloid which is close to sulfur (S) in terms of properties. The Se concentration in soil varies with type, texture and organic matter content of the soil and with rainfall. Its assimilation by plants is influenced by the physico-chemical properties of the soil (redox status, pH and microbial activity).
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Plants, selenium and human health
Selenium is an essential nutrient for animals, microorganisms and some other eukaryotes. Although selenium has not been demonstrated to be essential in vascular …
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Selenium in Biology: Facts and Medical Perspectives
Selenium in Biology: Facts and Medical Perspectives
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Selenium in biology: facts and medical perspectives
Selenium in biology: facts and medical perspectives. Several decades after the discovery of selenium as an essential trace element in vertebrates approximately 20 …
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The Role of Selenium in Pathologies: An Updated Review
Selenium is used in biology mainly in the form of selenocysteine, a true proteogenic amino acid bearing the selenol functionality (SeH), which is inserted into selenoproteins. Selenocystein is also used as a ligand for the molybdopterin guanine dinucleotide cofactor of formate dehydrogenase, for nickel in [NiFeSe] hydrogenases, as …
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The Selenoprotein Glutathione Peroxidase 4: From Molecular …
To capture the growing landscape of GPX4 biology and its impact as a therapeutic target, where appropriate, we refer readers to recent reviews for a more detailed discussion. ... elemental selenium was discovered to play a key role in enzymatic activity [4,5,6,7]. This enzyme is known today as GPX1, and it is recognized as the most efficient ...
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Selenium: An Element of Life Essential for Thyroid Function
1. Introduction. Selenium (Se) is an essential micronutrient, necessary for the maintenance of different cellular functions (e.g., immune–endocrine function, signaling transduction pathways), although it is toxic like elemental Se as well as Se salts (even in small doses) [].The thyroid gland is particularly rich in Se, which takes part in the …
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Nutrients | Free Full-Text | Selenium, Selenoproteins, and …
Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The …
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An Overview of Selenium Uptake, Metabolism, and Toxicity in Plants
Selenium (Se) is an essential micronutrient for humans and animals, but lead to toxicity when taken in excessive amounts. Plants are the main source of dietary Se, but essentiality of Se for plants is still controversial. ... Selenium metabolism in plants, in Cell Biology of Metal and Nutrients, eds Hell R., Mendel R.(Berlin: Springer; ), 225 ...
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Selenium
Main article: Selenium in biology. A number of correlative epidemiological studies have implicated selenium deficiency (measured by blood levels) in a number of serious or chronic diseases, such as cancer, diabetes, HIV/AIDS, and tuberculosis. In addition, selenium supplementation has been found to be a chemopreventive for some types of cancer ...
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Plants, selenium and human health
Selenium (Se) is an essential nutrient for animals, humans, and microorganisms. Interest in Se has historically focused on its toxicity, and this is especially important in the southwest United States where soils that contain naturally high concentrations of Se soils. ... Although the recent increase in research on Se biology in …
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The role of selenium in human conception and pregnancy
Selenium (Se) is a trace element essential for the appropriate course of vital processes in the human body. It is also a constituent of the active center of glutathione peroxidase that protects cellular membranes against the adverse effects of H2O2 lipid peroxides. Epidemiological surveys have demonstrated that selenium deficiency in the body ...
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Microbial selenium metabolism: a brief history, biogeochemistry …
The year 1973 proved to be a banner year for research on the role of selenium in biology, as multiple independent lines of inquiry identified specific biochemical functions for selenium assimilation in both mammals and bacteria. The mammalian enzyme glutathione peroxidase, ...
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Selenium
Selenium - Health Professional Fact Sheet. 2, 5, 8, 21 ]. Before the Chinese government supplementation program, adults in the Keshan disease areas had average selenium intakes of no more than 11 mcg/day; intakes of at least 20 mcg/day protect adults from Keshan disease [ 6 ]. Selenium deficiency is also associated with male infertility and ...
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Selenium in Biology and Medicine
In July, 1988, more than 300 scientists from 29 different countries gathered at Tiibingen, W. Germany, in order to spend 4 days discussing their favourite trace element, selenium. This meeting continued the good tradition of three previous meetings held in Corvallis/Oregon, 1976, in Lubbock/Texas, 1980, and in Beijing/China, in 1984.
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