آخرین محصولات
Mesoporous silica nanoparticles deliver DNA and chemicals into …
Surface-functionalized silica nanoparticles can deliver DNA 1,2,3,4,5,6,7,8 and drugs 9,10,11,12,13,14,15 into animal cells and tissues. However, their use in plants is limited by the cell wall ...
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Cellular Fate of a Modular DNA Delivery System Mediated by Silica
Abstract Development of efficient molecular medicines, including gene therapeutics, RNA therapeutics, and DNA vaccines, depends on efficient means of transfer of DNA or RNA into the cell. Potential...
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Durable multitransgene expression in vivo using systemic, nonviral DNA
In contrast to viral vector-based gene delivery approaches, nonviral DNA-based approaches have very large DNA insert capacity (1, 2) and the ability to efficiently reexpress reinjected genes in immunocompetent hosts (3, 4).Nonviral, systemic DNA-based approaches typically use cationic polymers or lipids to mediate delivery, either …
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A self-assembled, modular DNA delivery system mediated by …
The first successful step towards this modular synthetic DNA delivery system is demonstrated: a three-component transfection system mediated by silica nanoparticles. Dense silica nanoparticles serve as an uptake-enhancing component by physical concentration at the cell surface; enhanced transfection due to the particles is seen with …
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DNA Nanostructures as Smart Drug-Delivery Vehicles and …
DNA origami self-assembly drug delivery cell uptake immunostimulation enzymatic payloads biosensing biocomputing Emerging DNA Nanotechnology The field …
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Cellular fate of a modular DNA delivery system mediated by silica
To better design synthetic carriers, or transfection reagents, the modular design of viruses has inspired a modular approach to DNA and RNA delivery. Each modular component can be designed to circumvent each of the many barriers. The modular approach will allow modification of individual components for a specific application.
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Cellular Fate of a Modular DNA Delivery System Mediated by …
surrounding viral methods of DNA delivery have necessitated the use of nonviral, synthetic carriers. To better design synthetic carriers, or transfection reagents, the modular design of viruses has inspired a modular approach to DNA and RNA delivery. Each modular component can be designed to circumvent each of the many barriers.
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Cellular Fate of a Modular DNA Delivery System Mediated by …
By showing that the modular system based upon concentration of DNA at the level of the cell can be used to increase transfection efficiency, we have shown that …
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Piperazine-derived lipid nanoparticles deliver mRNA to immune …
Here we use Fast Identification of Nanoparticle Delivery (FIND) 32, a DNA barcode-based high-throughput LNP screening system, to characterize how 65 chemically distinct LNPs functionally deliver ...
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Programmable Transformations of DNA Origami Made of …
programmable reconfiguration of the overall dimensions and curvatures of DNA origami. The modular design of programmable shape transformation of DNA origami can find potential applications in more sophisticated molecular nanorobots and smart drug delivery nanocarriers. INTRODUCTION Dynamic DNA nanotechnology has witnessed great …
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Modular protein-DNA hybrid nanostructures as a drug delivery …
Herein, we present the modular design and assembly of functional DNA nanostructures through sequence-specific interactions between zinc-finger proteins (ZnFs) and DNA as a cytosolic drug delivery platform. Three kinds of DNA-binding ZnF domains were genetically fused to various proteins with different biological roles, including …
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A self-assembled, modular DNA delivery system mediated by …
A modular approach, using biocompatible synthetic materials to mimic viral vectors for efficient DNA delivery, may be useful. The modular approach requires at …
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Janus USPION modular platform (JUMP) for theranostic
DNA/RNA-therapies can provide potential breakthroughs, however, to date, there is no FDA-approved systemic delivery system to solid tumors. Methods: Here, we report a Janus-nanoparticle (jNP)-system with modular targeting, payload-delivery, and targeted-imaging capabilities. Our jNP-system consists of 10 nm ultrasmall …
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Janus USPION modular platform (JUMP) for theranostic …
The covalently layered jNP-design attains ~ 3-fold smaller size than reported Janus nanoparticles and displays multiple advantages not attained in other nucleic-acid delivery systems. First, DNA/miRNA delivery is attained in vitro and in vivo safely using 6-fold less nucleic-acid payloads (~ 30 μg/rat) and 10-fold fewer microbubbles at 10 8 ...
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Three-dimensional DNA tweezers serve as modular DNA …
Because of the unique DNA tetrahedral framework, TD-tweezers showed significantly enhanced biological stability and cellular delivery efficiency, which are prerequisites for DNA intelligent machine use in in vivo applications. In addition, the modular design allows us to add components such as regulatory components to their …
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Programmable molecular transport achieved by engineering
We used a modular protein–engineering approach to create hybrid motors that move on DNA nanostructures (16–18).We chose dynein as an engine because it consists of several modules with distinct roles, including hydrolysis of ATP and binding to the track (18–20).We replaced the original track-binding domain of monomeric human …
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Modular Lipid Nanoparticle Platform Technology for siRNA and …
A major advantage of LNPs is the interchangeability of its building blocks and RNA payload, which allow it to be a highly modular system. In addition, drug derivatization approaches can be used to synthesize lipophilic small molecule prodrugs that stably incorporate in LNPs.
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Cellular fate of a modular DNA delivery system mediated by silica
By showing that the modular system based upon concentration of DNA at the level of the cell can be used to increase transfection efficiency, we have shown that further …
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Nanoparticle‐mediated gene transformation strategies for plant …
Furthermore, the DNA nanostructure technique is modular, flexible and easy to perform in plants ... The cargoes (DNA/RNA) can be placed inside or outside the DNA nanoparticles and the nanoparticle-based DNA/RNA delivery systems can transport the cargoes across the lipid bilayer of the cell membrane, allowing it to reach the nucleus …
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Engineering synthetic RNA devices for cell control
Components of synthetic RNA devices. A major research focus in synthetic biology is the development of modular frameworks for constructing genetically encoded devices and engineered biological ...
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Automated Modular Synthesis of Aptamer–Drug Conjugates for …
Aptamer–drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug–aptamer conjugation. To solve such problems, we have …
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The biological applications of DNA nanomaterials: current …
Introduction. DNA was used for the storage of genetic information as a common biomolecule and fundamental hereditary material in different creatures. 1,2 DNA materials possess the potential for nanofabrication due to its characteristic nature, i.e., high precision of Watson–Crick base-pairing and high controllability. 1,3–5 In 1980s, Seeman …
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Cellular Fate of a Modular DNA Delivery System Mediated by …
Borrowing the modular aspect of a virus, a ternary, modular DNA delivery system has been developed utiliz-ing DNA, dendrimer, and silica nanoparticles (8, 9). The specifics of the system have been guided by a mathemati-cal model that describes optimal nanoparticle number and size. Silica nanoparticles are utilized due to their
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DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular
The successful delivery of DNA-based structures into cells opens new avenues for tackling diverse medical tasks. Jiang et al. [31] and Zhang et al. [32] managed to deliver doxorubicin – an anticancer drug and a DNA intercalator – into cells in vivo using rod-like DNA origamis or DNA origami triangles as carriers (Figure 1 B). Zhao et al. [33] …
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Cellular Fate of a Modular DNA Delivery System Mediated by Silica
To better design synthetic carriers, or transfection reagents, the modular design of viruses has inspired a modular approach to DNA and RNA delivery. Each modular component can be designed to circumvent each of the many barriers. The modular approach will allow modification of individual components for a specific application.
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Novel modular transporters delivering anticancer drugs and foreign DNA
Modular transporters for targeted subcellular delivery of foreign DNA Concerning modules of DNA transporters ( Table 2 ), special requirements are imposed on the carrier module: it should reversibly condensate the DNA to be transported in such a way as to permit internalization of the whole DNA-transporter complex and subsequent sufficient gene ...
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Direct delivery and fast-treated
Procedure 1: modular Golden Gate assembly of T-DNA vector Steps 1–3, design sgRNA(s) for target gene: 1 day Steps 4–14, cloning synthesized oligos into tRNA MoClo compatible vectors: 3 d
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Cell type-specific delivery by modular envelope design
Here, we describe DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design), a modular platform for achieving programmable cell …
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Modular cell-internalizing aptamer nanostructure enables targeted
Here we show results from the design and characterization of a modular nanostructure for the aptamer-mediated intracellular delivery of large functional RNA payloads (~50–80 kDa) in live cells.
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3D RNA-scaffolded wireframe origami | Nature Communications
Bottom-up design of RNA-scaffolded origami has been demonstrated using RNA staples to form 2D structures 57 and single-duplex-edged 3D wireframe structures 58, and using DNA staples to form ...
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